| Buffalo at Denver | ||
| BUF | PROBABLE | CB Nate Clements (Chest) T Mike Williams (Knee) |
| DEN | PROBABLE | G Lennie Friedman (Thumb) WR Kevin Kasper (Rib) C Tom Nalen (Knee) T Ephraim Salaam (Ankle) OLB Donnie Spragan (Concussion) MLB Al Wilson (Knee) |
| Carolina at Minnesota | ||
| CAR | OUT | RB DeShaun Foster (Knee) K John Kasay (Hernia) |
| QUESTIONABLE | DE Kemp Rasmussen (Hamstring) | |
| PROBABLE | SS Jarrod Cooper (Back) DT Sean Gilbert (Knee) G Jeno James (Shoulder) DE Mike Rucker (Ankle) CB Dante Wesley (Hernia) | |
| MIN | OUT | FB Jim Kleinsasser (Knee) DT Talance Sawyer (Knee) |
| QUESTIONABLE | TE Byron Chamberlain (Knee) OLB Patrick Chukwurah (Chest) | |
| PROBABLE | WR Nick Davis (Hamstring) T Everett Lindsay (Back) | |
| Cincinnati at Atlanta | ||
| CIN | OUT | WR Danny Farmer (Knee) |
| QUESTIONABLE | DE Vaughn Booker (Leg) | |
| PROBABLE | RB Brandon Bennett (Ankle) SS Cory Hall (Thumb) WR T.J. Houshmandzadeh (Groin) DE Eric Ogbogu (Calf) OLB Takeo Spikes (Chest) WR Peter Warrick (Leg) DT Bernard Whittington (Foot) | |
| ATL | OUT | C Roberto Garza (Foot) DE Travis Hall (Groin) OLB Will Overstreet (Shoulder) |
| DOUBTFUL | CB Allen Rossum (Hamstring) | |
| PROBABLE | CB Juran Bolden (Quadricep) SS Johndale Carty (Thumb) OLB John Thierry (Hip) | |
| Cleveland at Tennessee | ||
| CLE | QUESTIONABLE | SS Chris Akins (Groin) T Roger Chanoine (Knee) DT Alvin McKinley (Ankle) T Ryan Tucker (Knee) C Dave Wohlabaugh (Hand) |
| PROBABLE | DE Courtney Brown (Neck) QB Tim Couch (Forearm) FB Aaron Shea (Shoulder) OLB Ben Taylor (Hamstring) | |
| TEN | OUT | RB Robert Holcombe (Hip) DE Jevon Kearse (Foot) |
| QUESTIONABLE | CB Andre Dyson (Hamstring) RB Eddie George (Foot) MLB Randall Godfrey (Ankle) TE Erron Kinney (Ankle) QB Steve McNair (Neck) TE Shad Meier (Shoulder) DT Robaire Smith (Elbow) | |
| Dallas at Philadelphia | ||
| DAL | OUT | MLB Dat Nguyen (Wrist) T Tyson Walter (Ankle) |
| DOUBTFUL | T Aaron Gibson (Shoulder) | |
| QUESTIONABLE | G Larry Allen (Ankle) SS Tony Dixon (Hamstring) CB Dwayne Goodrich (Quadricep) | |
| PROBABLE | CB Duane Hawthorne (Hamstring) WR Reginald Swinton (Hamstring) | |
| PHI | OUT | DE Derrick Burgess (Foot) WR Freddie Milons (Leg) G John Welbourn (Leg) |
| QUESTIONABLE | CB Lito Sheppard (Quadricep) RB Brian Westbrook (Abdomen) | |
| PROBABLE | OLB Carlos Emmons (Hamstring) C Hank Fraley (Quadricep) | |
| Green Bay at Detroit | ||
| GB | OUT | T Mark Tauscher (Knee) |
| QUESTIONABLE | RB Ahman Green (Quadricep) | |
| PROBABLE | NT Gilbert Brown (Knee) SS Antuan Edwards (Shoulder) DE Kabeer Gbaja-Biamila (Rib) CB Bhawoh Jue (Ankle) TE David Martin (Jaw) FS Darren Sharper (Ankle) CB Tyrone Williams (Ankle) | |
| DET | OUT | DT Shaun Rogers (Hand) |
| DOUBTFUL | WR Bill Schroeder (Ribs) | |
| QUESTIONABLE | RB Aveion Cason (Knee) CB Eric Davis (Hamstring) OLB Barrett Green (Elbow) WR Desmond Howard (Neck) OLB Clint Kriewaldt (Foot) | |
| Indianapolis at Houston | ||
| IND | OUT | FB Jim Finn (Foot) DT Josh Williams (Foot) |
| DOUBTFUL | DT James Cannida (Knee) | |
| QUESTIONABLE | OLB Mike Peterson (Knee) | |
| PROBABLE | FS Idrees Bashir (Hamstring) SS Cory Bird (Ankle) RB Edgerrin James (Ankle) TE Marcus Pollard (Chest) FB Detron Smith (Shoulder) OLB David Thornton (Shoulder) K Mike Vanderjagt (Groin) WR Reggie Wayne (Head) | |
| HOU | OUT | G Ryan Schau (Knee) T Ryan Young (Groin) |
| DOUBTFUL | T Tony Boselli (Shoulder) | |
| PROBABLE | T Jimmy Herndon (Hip) MLB Jason Lamar (Calf) TE Sean McDermott (Ankle) TE Billy Miller (Ankle) | |
| Kansas City at New England | ||
| KC | QUESTIONABLE | RB Derrick Blaylock (Knee) NT Eric Downing (Abdomen) TE Jason Dunn (Shoulder) |
| PROBABLE | TE Tony Gonzalez (Wrist) DE Eric Hicks (Ankle) | |
| NE | QUESTIONABLE | OLB Roman Phifer (Leg) |
| PROBABLE | MLB Tedy Bruschi (Shoulder) WR David Givens (Leg) | |
| New Orleans at Chicago | ||
| NO | OUT | CB Keyuo Craver (Knee) RB Fred McAfee (Hamstring) |
| QUESTIONABLE | DE Darren Howard (Shoulder) CB Fred Thomas (Hand) | |
| CHI | OUT | DE Phillip Daniels (Ankle) CB R.W. McQuarters (Knee) WR Ahmad Merritt (Hand) DT Ted Washington (Ankle) |
| QUESTIONABLE | T James Williams (Hip) | |
| New York at Miami | ||
| NYJ | QUESTIONABLE | CB Jamie Henderson (Shoulder) FS Damien Robinson (Groin) T Chris Smith (Knee) |
| PROBABLE | WR Laveranues Coles (Knee) G J.P. Machado (Thumb) G Randy Thomas (Groin) | |
| MIA | OUT | TE Desmond Clark (Forearm) |
| QUESTIONABLE | SS Scott McGarrahan (Groin) OLB Twan Russell (Knee) CB Patrick Surtain (Knee) | |
| PROBABLE | DE David Bowens (Hand) T Mark Dixon (Ankle) CB Omare Lowe (Ankle) DE Jason Taylor (Neck) T Todd Wade (Ankle) FS Shawn Wooden (Shoulder) | |
| San Diego at Arizona | ||
| SD | DOUBTFUL | SS Rodney Harrison (Groin) CB Tony Okanlawon (Leg) T Sammy Williams (Hamstring) |
| QUESTIONABLE | G Toniu Fonoti (Shoulder) | |
| PROBABLE | TE Stephen Alexander (Concussion) CB Tay Cody (Ankle) G Bob Hallen (Groin) DE Marcellus Wiley (Ankle) | |
| ARI | OUT | T Anthony Clement (Arm) OLB Levar Fisher (Knee) FB Dennis McKinley (Hamstring) |
| QUESTIONABLE | CB David Barrett (Back) T L.J. Shelton (Ankle) | |
| PROBABLE | WR David Boston (Ankle) C Mike Gruttadauria (Back) RB Thomas Jones (Ankle) C Jason Starkey (Concussion) DE Kyle Vanden Bosch (Ankle) | |
| Seattle at New York | ||
| SEA | OUT | OLB Anthony Simmons (Ankle) |
| DOUBTFUL | DT John Randle (Knee) | |
| QUESTIONABLE | DE Brandon Mitchell (Calf) | |
| NYG | QUESTIONABLE | WR Tim Carter (Ribs) CB William Peterson (Toe) C Dusty Zeigler (Knee) |
| PROBABLE | DT Cornelius Griffin (Rib) OLB Kevin Lewis (Ankle) | |
| Washington at San Francisco | ||
| WAS | OUT | TE Walter Rasby (Knee) |
| DOUBTFUL | OLB Antonio Pierce (Ankle) | |
| QUESTIONABLE | DT Daryl Gardener (Back) QB Shane Matthews (Shoulder) G Kipp Vickers (Knee) | |
| PROBABLE | T Chris Samuels (Groin) DT Dan Wilkinson (Wrist) | |
| SF | OUT | FB Paul Smith (Hamstring) T Matt Willig (Knee) |
| PROBABLE | FS Zack Bronson (Shoulder) G Eric Heitmann (Neck) C Jeremy Newberry (Calf) G Ron Stone (Hamstring) ILB Jeff Ulbrich (Knee) | |
| St. Louis at Tampa Bay | ||
| STL | OUT | FB James Hodgins (Foot) |
| PROBABLE | FS Chad Cota (Chest) CB Dexter McCleon (Leg) C Andy McCollum (Foot) G Tom Nutten (Concussion) OLB Tommy Polley (Groin) CB Aeneas Williams (Toe) | |
| TB | PROBABLE | G Cosey Coleman (Knee) TE Ken Dilger (Tricep) SS David Gibson (Ankle) SS John Lynch (Quadricep) NT Anthony McFarland (Hip) DE Simeon Rice (Shoulder) |